Liquid chromium picolinate12/8/2023 Thus, the OZR can serve as a useful animal model for determination of potential influences of therapies aimed at prevention or attenuation of obesity/type 2 diabetes-related abnormalities. The OZR display marked obesity, dyslipidemia, severe insulin resistance, increased oxidative stress and a proinflammatory state compared to the lean Zucker rats (LZR). The OZR have an autosomal recessive mutation of the fa gene encoding the leptin receptor. Of various animal models of obesity and type 2 diabetes mellitus, the obese Zucker rats (OZR) have been used extensively for studies focused on consequences of the disease and the contributing mechanisms. Further, obesity is known as a pro-inflammatory state thereby contributing importantly to eventual target organ manifestations and associated morbidity and mortality. In turn, obesity and impaired glucose tolerance/type 2 diabetes markedly increase the risk for development of renal and cardiovascular complications. The worldwide epidemic of obesity is a major predisposing factor for the ever increasing prevalence and incidence of glucose intolerance and type 2 diabetes. Conclusionĭietary Cr(pic)3 treatment of OZR does not beneficially influence glycemic status or increase the risk for oxidative DNA damage rather, the treatment attenuates indices of oxidative stress and inflammation. Finally, increased renal nitrotyrosine and cyclooxygenase-2 levels and urinary excretion of monocyte chemoattractant protein-1 of OZR were partially reversed by Cr(pic)3 treatment. However, immunostaining of kidney for 8-OHdG revealed similar staining pattern and intensity, despite significant renal accumulation of chromium in Cr(pic)3-treated groups. Urinary excretion of 8-hydroxydeoxyguanosine (8-OHdG), an index of oxidative DNA damage, was greater in the OZR than LZR dietary Cr(pic)3 treatment attenuated 8-OHdG excretion. Also, other indices of renal function or histopathology were not affected by Cr(pic)3 treatment. The OZR, irrespective of Cr(pic)3, excreted more albumin than LZR. The OZR displayed increased fasting plasma glucose and insulin in association with enlarged pancreatic islets exhibiting collagen and periodic acid Schiff-positive deposits compared to LZR Cr(pic)3 treatment did not affect these parameters. Glycemic and renal effects of Cr(pic)3 were determined in the context of indices of oxidative stress and inflammation. Male OZR were treated with diets lacking or containing 5 and 10 mg/kg of chromium, as Cr(pic)3, for 20 weeks lean Zucker rats (LZR) served as controls. Therefore, we tested the hypothesis that Cr(pic)3 treatment of obese Zucker rats (OZR) exacerbates renal abnormalities associated with dysglycemia. Potential toxicity of Cr(pic)3 should be greater for the kidney that accumulates chromium. Store at room temperature away from moisture and heat.Chromium picolinate (Cr(pic)3) is advocated as adjuvant therapy for impaired glycemic control, despite concerns for DNA damage. Follow your diet, medication, and exercise routines very carefully. Department of Agriculture's "Dietary Reference Intake" (formerly "Recommended Daily Allowances" or RDA) listings for more information.Ĭr-GTF may be only part of a treatment program that may also include diet, exercise, and weight control. You may also consult the National Academy of Sciences "Dietary Reference Intake" or the U.S. Follow your healthcare provider's instructions. The recommended dietary allowance of chromium picolinate increases with age. Do not use more of this product than is recommended on the label.Ĭheck your blood sugar carefully if you are diabetic. If you choose to use Cr-GTF, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements. When considering the use of herbal supplements, seek the advice of your doctor. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.Ĭr-GTF may also be used for purposes not listed in this product guide. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. This medicine should not be used in place of medication prescribed for you by your doctor.Ĭr-GTF is often sold as an herbal supplement. Not all uses for Cr-GTF have been approved by the FDA. The body needs only trace amounts of chromium, and deficiency of this mineral in humans is rare.Ĭr-GTF works together with insulin produced by the pancreas to metabolize carbohydrates.Ĭr-GTF has been used in alternative medicine to treat chromium deficiency, as an aid to controlling blood sugar in people with diabetes or prediabetes, to lower cholesterol, and as a weight-loss supplement. Chromium is a mineral found in certain foods.
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